Destroy All Humans! is one of my favorite games of 2005. My only complaint was that it was too short (you can rent it and finish the entire game in one weekend) but it sold very well, and I hoped that a sequel result. I hoped so much, I was willing to "get my coat."
Looks like my deal with the Robot Devil is about to pay off:
Destroy All Humans Sequel Coming in Fall
The sequel will be set in 1960s Europe, where Crypto will face off against ninjas, hippies, communists, and Godzilla-style mutant monsters.