Many years ago, when I attended my first or second San Diego Comicon (and met Loren and Ben, who were instrumental in the creation of WWdN) I met the guys behind Penny Arcade.
Even though I'm not an especially active video or online gamer (except poker, which I wasn't playing online when I met them) I have always enjoyed Penny Arcade, because -- like pVp and Dork Tower -- it has characters I can care about and relate to while I'm laughing at myself, or them, or (usually) both.
I talked to Gabe and Tycho for a few minutes that year, did the obligatory geek out, and then got out of the way, because there were literally hundreds of fans who wanted to meet them and give them money. I guess I made an impression on them, because they featured me in one of their comics, which Gabe or Tycho drew on the plane home, and sent me via e-mail (I can't remember who and it's not really important enough to unpack e-mail archives from that long ago to find out. Also if I'm vague enough about it, maybe one of them will ping me and put me in a new comic. How's that for attention whoring?! Very nice.)
I'm sure I linked it way back in the Where's My Burrito days, but my story about Jonathan crashing into the turbolift door in my review of Hide and Q prompted a few WWdN:iX readers to remind me about that one time I was in Penny Arcade.
My absolute favorite moment in the whole strip is the reaction from the two of them after I deliver the title of this post; it's a great example of being able to relate to the characters while laughing simultaneously at myself. It's also just good artwork that captures clear emotion in a simple drawing without any words at all.